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P. N. Kavitha ¹, S. Mohan ¹, J. Saravanan ¹, Subhajit Dutta ¹

Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN

Abstract

2-amino (4-chloro phenyl)thiazoles were synthesized by brominating p-chloroaceto phenone to give p-chloro phenacyl bromide which was then reacted with thiourea in microwave synthesizer to give 2-amino (4-chloro phenyl) thiazoles(II). Later the compound II were treated with ten different substituted aryl aldehydes to yield ten new Schiff bases (III). The compounds were characterized by IR, ¹H NMR and Mass spectral data. Investigation on the antimicrobial activity of these compounds was determined by cup plate method against bacteria and fungi. Among the compounds tested, five compounds exhibited significant antimicrobial activity.

Keywords

Synthesis, Thiazoles, Schiff Bases, Antimicrobial Activity.

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